Abstract
Summary
Mice with congenitally-acquired LCM virus infection were maintained under germfree condtions for 12 months. With advancing age, the mice showed histological evidence of uncontrolled immunoproliferative changes: the enlarged lymph nodes and spleens contained large germinal zones and numerous plasma cells. The cortical cells of the thymus glands were progressively depleted of cortical cells, became shrunken, eventually swollen, and infiltrated with large plasma cells. The visceral organs had perivascular infiltrations of lymphoid and plasma cells which displaced significant amounts of parenchyma. The plasmacytomas which developed differed from the lesions associated with murine leukemia.
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