Abstract
Summary
Aminoglutethimide, when given by stomach tube daily to rats for 7 weeks beginning immediately after adrenal enucleation, reduced markedly the development of adrenal regeneration hypertension. This effect was not due to a reduction of intake of salt drinking solutions. Relative to controls, the drug did not influence renal, cardiac, or thyroid weights. It is postulated that the drug inhibited the secretion of an as yet unidentified steroid that causes adrenal regeneration hypertension.
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