Abstract
Summary
Previous studies showed overlapping values of G-6-PDH activity in normal and malignant tissues. This is confirmed by the present work. Malignancy may be accompanied by high G-6-PDH activity; similar values, however, may be found in embryonic tissues, spleen, and in primary lung explants after a few days of cultivation in vitro. In long-term cultures a further increase in G-6-PDH activity was seen. Although the G-6-PDH activity was usually high in cells and tissues with a high glycolytic capacity, the observations do not indicate a direct correlation between glycolysis and G-6-PDH activity or between acetate incorporation and G-6-PDH activity in tissue cultured cells.
This work was supported by grants from the Daell Foundation, the Danish National Research Foundation and the Jorck Foundation. The generous support of Dr. J⊘rgen Kieler and the excellent technical assistance of Miss Jette Pedersen is gratefully acknowledged.
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