Abstract
Summary
Respiratory and phosphorylat-ing activities were determined in liver mitochondria from mild and severely diabetic rats. Diabetes was caused by 95% pancreatectomy performed 6-18 months before the investigation of mitochondrial function. Diabetic mitochondria showed depressed respiratory rates with β-hydroxybutyrate, L-malate-L-glutamate, and succinate as substrates while the P:O ratios did not depart from the normal control values, with all the employed substrates. Ubiquinone levels were significantly increased in mitochondria from severely diabetic rats while cytochrome c and mitochondrial protein remained unchanged.
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