Abstract
Summary
The effect of graded doses of parathyroid extract and calciferol upon thyroxine secretion rate (TSR) of normal female rats was studied with the aid of radioactive iodine 131I. Administration of 20, 30, and 40 USP units of PTE/100 g of body wt/day for 14 days induced a significant (p<.025) increase in TSR of 25.4, 35.6, and 54.1%, respectively, over their own controls associated with slight increase in body weight. Administration of calciferol (Vit. D2) in doses of 0.1, 0.15, and 0.2 mg/100 g of body wt induced a nonsignificant reduction in TSR of the first two groups (groups IV and V) but a significant 26.7% (p<.05) increase in TSR above their own control in group VI associated with loss of body weight of 14.2% when 0.2 mg calciferol/100 g of body wt was given daily for the same period. A nonsignificant increase in weight of ovaries, uteri, and a decrease of thymus glands with significant increase in thyroid and adrenal weights was noticed in the group treated with 0.2 mg of calciferol/100 g of body wt as compared to 0.1 mg of calciferol/100 g of body wt.
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