Abstract
Summary
When killed gram-negative bacilli (EMB-1) were injected into California spiny lobsters (Panulirus interruptus) an induced bactericidin appeared in the hemo-lymph. This reached a maximum level within 7 days after the primary injection and persisted without further stimulation for at least 60 days. Some elevation of bactericidal titers followed secondary injections of the same bacteria after 60 days. This rise was reminiscent of the anamestic response in antibody synthesis of higher vertebrates. Specificity of the response was not absolute, but the degree of induced reactivity decreased in the order: homologous inoculum (EMB-1) > Salmonella typhosa > bovine serum albumin. The response to bovine serum albumin was no greater than a sham control or those controls inoculated with sodium chloride-formalin solution.
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