Abstract
Summary
The jack bean phytohemagglutinin, concanavalin A, induced histamine lethality in CFW mice. Sensitization depended upon the dose of concanavalin A, with an LD50 of 0.5 mg. The sensitization was time dependent, reaching a maximum at 4 days and declining at 6 days. An inhibitor of concanavalin A-polysaccharide precipitin interactions, D-glucose, had no effect on the sensitization. Concanavalin A did not alter the sensitization of mice by B. pertussis.
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