Abstract
Summary
Venom of the brown recluse spider, Loxosceles reclusa, contains a potent inhibitor of hemolytic complement activity in vitro. Up to 2 CH50 units of C'activity in human, rabbit, and guinea pig sera could be maximally inhibited by 0.016-0.300 μg venom protein per ml. The venom factor is nondialyzable, excluded from Sephadex G75, and is relatively stable over a wide range of pH, heat, and storage conditions.
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