Abstract
Summary
In rats the ED50 values for the antifertility activity of 2,3-bis(4-hydroxy-phenyl) valeronitrile (SC-3296) injected subcutaneously from Day 1–3, Day 4–7, or Day 1–7 of pregnancy were 50, 100, and 12 μg respectively and those of 2,3-bis(4-methoxy-phenyl)pent-2-enenitrile (SC-3402) given for the same treatment periods were 100, 300, and 40 μg, respectively. Both compounds also prevented pregnancy in rabbits, but only SC-3402 was effective in hamsters. On the basis of the number of ova recovered from rats after flushing the reproductive tract, daily treatment with 5 μg of estrone, 64 μg of SC-3296, and 200 μg of SC-3402 accelerated ova transport. This effect appears to be independent of the weak estrogenic properties of SC-3402 but not of SC-3296. The delay of implantation, produced by 17α-acetoxy-6α-methylprogesterone, was interrupted by 50 μg of SC-3296 injected from Day 5–9 of pregnancy but not by 200 μg of SC-3402 or by 1 μg of estrone after treatment with SC-3402. Blastocysts were absent from flushings obtained from the uteri of the latter two groups even after ligation of the uterus at the cervix. Morphologically, no adverse effects on the preimplantation stages of the developing ova were observed. SC-3402 (200 μg) inhibited the formation of deciduoma in the rat.
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