Abstract
Summary
The pressor responses to cisternally injected veratrine in dogs was effectively blocked by previous cisternal injection of hexamethonium in doses of 2 mg/kg but not by intravenous doses of 10 mg/kg. A different ganglionic blocking agent, trimethaphan camphorsulfonate, in intravenous doses just adequate to block the effects of carotid occlusion, splanchnic stimulation, and nicotine injection, and which produced a marked fall in blood pressure, partially blocked the pressor response to veratrine. Additional doses of the blocking agent which produced severe blood pressure depression were required to completely block the veratrine pressor response.
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