Abstract
Summary
Endotoxin induced transient, tachyphylactic decreases in flow in rat livers perfused with whole blood. In contrast, no flow decrements accompanied endotoxin administration to livers perfused with rat erythrocytes in balanced salt solution, heparin-plasma, or balanced salt solution. By varying the combination of endotoxin and the major blood constituents, the hepatic vasoconstrictor response was found dependent on plasma, buffy coat cells, and endotoxin.
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