Abstract
Summary
The activity of 25 purine analogs was determined against human cytomegalovirus in vitro. Nineteen compounds were considered to have a degree of antiviral activity with seven of them markedly inhibiting both virus-induced cytopathogenic effects in WI-38 cells and the development of detectable virus. These seven compounds were 2-amino-9-β-d-ribofuranosyl-9H-purine-6-thiol, 2-aminopurine-6-thiol, 9-β-d-arabinofuranosyladenine, purine-6-thiol hydrate, purine-6-carboxaldehyde thiosemicarbazone, 2-amino-6-[(1-methyl-4-nitroimidazol-5-yl) thio] purine, and 9-β-d-ribofuranosyl-9H-purine-6-thiol. The active thiopurines protected the cells from virus infection if allowed to incubate with the cells 1 hr prior to addition of the virus. None of the compounds had demonstrable virucidal activity.
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