Abstract
Summary
Bradykinin administered intraportally produced transient decreases in flow in isolated rat livers perfused at constant pressure with either homologous blood or a balanced salt solution. The minimal effective dose of bradykinin in blood-perfused preparation was 0.5 μg; maximal effects were achieved with 25.0 μg. Flow decreases induced by bradykinin were greater in blood-perfused livers than in livers perfused with a balanced salt solution. Tachyphylaxis was demonstrated by the inability of a second bradykinin dose to produce prominent effects until 30 min after an initial vasoconstrictor dose.
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