Abstract
Summary
The serum corticosteroid response to small doses of human ACTH was studied in a group of healthy male volunteers whose endogenous ACTH production was suppressed with dexamethasone. Whereas the initial rate of rise and the time required for onset of rise of serum II-OHCS were independent of the dose of ACTH over a tenfold range (approximately 10-100 ng/kg of body weight), the maximum levels attained and the time required to reach these maxima were a direct function of the dose of ACTH employed.
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