Abstract
Summary
Experimental allergic encephalomyelitis (EAE) was produced by passive transfer of fully immunized lymph node cells into immunologically naive, isohistogenic recipients. Passive transfer of EAE was inhibited by X-radiation of recipients shortly after or 24 hr before the transfer. Inhibition depended on the dose of radiation. It did not require direct effects of radiation on the encephalitogenic lymph node cells or on the brain, or indirect effects through the adrenal. Inhibition was associated with massive destruction of the recipient's lymphoid and he-mopoietic systems, and may be related to deficient capacity for mounting an inflammatory reaction.
Get full access to this article
View all access options for this article.