Abstract
Summary
RML and CFW mice treated with 10–20 μg of saline extract (SE) from Bordetella pertussis have a total serum protein (TSP) level 0.5–1.0 g/100 ml serum less than that of normal mice. The drop in TSP seems to be principally due to a lowered serum albumin. The hypoproteinemia is maximal 1 day after SE treatment and does not last beyond 10–14 days. It does not appear to be a cause and effect relationship between hypoproteinemia and histamine hypersensitivity. The hypoproteinemia phenomenon may be another manifestation of the effects produced by the histamine-sensitizing factor from B. pertussis on basic cellular and metabolic mechanisms in the mouse.
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