Abstract
Summary
The antibody response to bovine serum albumin and the development of hyperglobulinemia following administration of intraperitoneal mineral oil separated BALB/c and A-mice from DBA, C57B1, and C3H mice. BALB/c mice developed many plasma cell tumors following intraperitoneal mineral oil injections. The A-mice developed 1/10 tumors but the peritoneal contents showed extensive phagocytosis of tumor cells. This phenomenon is observed in BALB/c mice only when tumor development is inhibited by administration of glycoprotein pituitary hormones. A hypothesis is developed to explain these observations.
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