Abstract
Summary
Primary and secondary immune responses occurred in rabbits following injection of type A human red cell stromata. Hemolytic activity against human B and O red cells also occurred, but not to the same extent seen for the type A red cells. Washed P. pestis bacilli stimulated a secondary, specific, anti-A hemolysin response only when they were harvested from a vaccine containing porcine peptones and peptides, in addition to beef heart extract. The data clearly show that P. pestis bacilli grown in media containing meat products contain an antigen similar to human Group A angien. Furthermore, the results suggest that Group A antigen, from these contaminating sources, is bound or incorporated in the bacterial cell surface.
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