Alteration of 14 C-Dextroamphetamine Sulfate Absorption by Carbonic Anhydrase Inhibition ∗

Abstract

Summary

Acetazolamide treatment does not increase the permeability of the blood-brain barrier to ¹⁴C-d-amphetamine but does alter the absorption of this drug from intraperitoneal and intraduodenal injection sites. The increased rate of absorption of d-amphetamine from the duodenum is inferred to be the result of a pH change produced by the inhibition of carbonic anhydrase.