Abstract
Summary
Ouabain was infused into the left renal artery of anesthetized dogs after removal of the right kidney. After 30 min of infusion the left kidney was removed and assayed for Na-K-ATPase in both cortex and medulla. Ouabain inhibited the enzyme from the cortex in a dose-dependent manner, while having no consistent effect on the enzyme from the medulla. The inhibition of cortical enzyme activity was positively correlated with increased sodium excretion and this correlation was statistically significant. These data are consistent with, but not conclusive proof of, the premise that Na-K-ATPase is the renal receptor for the natriuretic action of ouabain.
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