Abstract
Summary
Antibody to denatured (single stranded) DNA was detected in the serum of a majority of NZB/B1 mice. The frequency of this antibody in high titer increased in mice beyond 4 months of age. Three of 100 animals tested contained 10 μg/ml or more of single stranded DNA antigen in their sera. Additional precipitin systems were detected when sera from NZB/B1 mice were diffused against each other in agarose gel. The relationship of the antigens and antibodies demonstrated here to the pathogenesis of hemolytic disease in NZB/B1 mice is unknown. These observations should be considered in discussions of possible virus etiology and in pathogenetic mechanisms involving similar antigen-antibody systems in glomerulonephritis.
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