Abstract
Summary
The effects of nonpolar analogues of thio- and isothiocyanate on H+ secretion and microsomal ATPase of bullfrog gastric mucosa were studied and compared with those of thiocyanate anion. Methyl thio-cyanate reduced H+ secretion without any appreciable inhibitory effect on ATPase. There was no conversion of MeSCN to SCN- in gastric mucosa. The nonpolar derivatives of isothiocyanates inhibit H+ secretion irreversibly and are also potent inhibitors of the ATPase activity. These findings are consistent with the hypothesis that certain compounds containing a nitrogen atom with an unshared pair of electrons are inhibitors of H+ secretion. An anionic charge however is not a prerequisite for their inhibitory action. The effects of these nonpolar compounds on gastric H+ secretion are discussed in relation to their effects on gastric microsomal ATPase.
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