Stimulation of p -aminohippurate Transport by Slices of Rat Renal Cortex Following in Vivo Administration of Triiodothyronine ∗

Abstract

Summary

Administration of T₃ to weanling rats caused a marked increase in PAH transport in renal cortical slices but had no effect on NMN transport. When added directly to slices in vitro, T₃ inhibited PAH transport. The results therefore indicate that T₃ is transported as an organic acid and specifically stimulates the acid transport system, not by a generalized metabolic effect, but directly by substrate stimulation.