Effect of Angiotensin on the Denervated Kidney in the Dog ∗

Abstract

Summary

The renal effects of angiotensin were studied in anesthetized dogs with one kidney acutely denervated. Denervation was accomplished in each animal by sectioning all visible nerves leading to the left kidney. The response of the innervated kidney was compared to that of the denervated kidney before and during the intravenous infusion of angiotensin (0.025, 0.050, and 0.100 μg/kg-min). The kidneys were compared for urine flow (V), sodium excretion (U _NA V), glomerular filtration rate (C _IN) and effective renal plasma flow (C _PAH). During angiotensin infusion the mean decrease of C _PAH for the denervated side (21.9 ± 2.2 ml/min) was not statistically different from the fall measured for the innervated side (18.6 ± 2.1 ml/min). In all but one experiment, V and U _Na V changed in the same direction for both kidneys during the infusion of angiotensin. The denervated kidney did not display a greater diuresis nor natriuresis than the control kidney. These data indicate that renal denervation does not alter the vascular or excretory response to angiotensin infusion in the dog.