Abstract
Summary
In vitro characterization studies were carried out with the 9H virus (9HV) which is serologically related to rat virus (RV) and was recently isolated from rat leukemias produced by cell-free extracts of chemically induced rat mammary tumors. Experiments utilizing the techniques of density gradient centrifugation and temperature sensitivity revealed the presence in the 9HV preparations of two types of infectious hemagglutinating components, 9HV-A and 9HV-B, which differed in size and heat stability. Both were resistant to lipid solvents and a wide range of pH conditions, successive propagation of the 9HV-A in REL cell cultures resulted in the appearance of the 9HV-B. Further studies are required to determine the mechanism of this phenomenon. The serological and morphological relationships between the two components have not been delineated as yet.
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