Abstract
Summary
A systematic comparison of the capacity of trimethoprim to control established infections with the drug susceptible RO and primethamine resistant RO/PM strains of P. cynomolgi showed that the above pyrimidine has a significant order of activity against infections with the RO strain but, at the maximum tolerated dose, little capacity to control infections with the RO/PM. Thus contrary to expectations, based on results of earlier studies in bacterial systems and in human infections with P. falciparum, there is a considerable degree of cross resistance between trimethoprim and pyrimethamine.
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