Abstract
Summary
Experimental allergic encephalomelitis (EAE) in rats was used to study the immunosuppressive properties of 6-mercaptopurine (6-MP) and a glutamine antagonist, Duazomycin A (DZM), alone and in combination. The results indicate that while DZM alone had no immunosuppressive activity, it significantly enhanced the effectiveness of 6-MP in this disorder without increasing toxicity. The favorable results with this rational combination of antimetabolities in an experimental “auto-immune” disease associated with delayed hypersensitivity suggests similar applicability to disorders characterized by altered immune reactivity in man.
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