Abstract
Summary
The concentration of the lysosomal enzymes acid phosphatase, arylsulfatase B and β-glucuronidase, was determined in regenerating liver 1, 2, 3, and 10 days after partial hepatectomy. An obvious increase in enzymatic activity was observed 2-3 days after the operation, but the reactions of the different enzymes were not parallel. It is concluded that the lysosomal organelle as such does not participate in the initiation of the process of cell division. The enzymatic activities seem to be at their maximum at a point of time subsequent to mitotic division. The present results argue in favor of the view that the lysosomes play a part in a postmitotic autophagocytosis. It is suggested that the lysosomal enzymes are involved in the inhibition of the regeneration of the liver.
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