Abstract
Summary
In rats with chronic gastric fistulas, secretin completely inhibited the gastric acid response to both maximal and supramaximal doses of pentagastrin. In the rat as in the dog, therefore, secretin is a potent inhibitor of gastrin-stimulated secretion.
The effects of CCK on pentagastrin-stimulated secretion were mixed. An early inhibitory phase was followed by a period of stimulation. This twofold effect has also been noted in the dog and depends upon the background secretory activity.
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