Abstract
Summary
The presence of 1.0 μg/ml PLO during the adsorption period increased the resulting plaque numbers of VSV severalfold over that of PLO free controls. The enhancement was demonstrated on both CEF and MSF in the absence of detectable cell toxicity, occurred at both 4 and 37°, was manifest with as little as a 5-sec adsorption period, and could be completely inhibited by the simultaneous presence of heparin. Treatment of cells alone, but not virus alone, prior to the adsorption period, resulted in similar but less enhancement in the number of plaques. It appears that 1 μg/ml of PLO alters a cell monolayer so that certain viruses will have an enhanced rate of attachment.
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