Abstract
Summary
Hypoglycemia, per se, does not seem to explain the histamine sensitivity which occurs in mice after treatment with fractions or whole cell preparations of Bordetella pertussis. Onset and duration of histamine sensitivity were earlier and longer lasting, respectively, than those of the hypoglycemia which resulted from treatment with an alkaline saline extract (SE) of B. pertussis. Insulin-induced hypoglycemia which was equal to or even 4.1 times greater than that resulting from SE treatment did not sensitize mice to histamine. The SE-treated mice made hyperglycemic with d-mannoheptulose, a short-term diabetogenic agent, were not protected from the lethal effects of histamine challenge.
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