Abstract
Summary
Oxonic acid and allantoxaidine were potent in vivo inhibitors of uricase. Oxonic acid, when fed to rats or injected intraperitoneally, produced a marked increase in blood plasma urate levels and urinary uric acid output with a concomitant decrease in urinary allantoin excretion. Addition of 5% oxonic acid plus 1% uric acid to the diet resulted in a 22-fold increase in urinary uric acid by day 23 of treatment with deposition of uric acid in the kidney tubules. The oxonic acid-treated rat may serve as a useful animal model for the study of hyperuricemia and hyperuricosuria.
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