Abstract
Summary
The effect of the renoprival state in the mother on renal growth of the fetus was studied in the progeny of mice uninephrectomized on day 14 of pregnancy. Fetal kidneys removed on day 17 and at birth (day 19) and the comparable solitary maternal kidney were analyzed for content of RNA and DNA. The ratio RNA/DNA (RNA/av cell) increased about 22% in the maternal kidney compared with sham-operated controls, but no change was found in fetal RNA/DNA. Therefore, either no humoral stimulus is produced as a consequence of maternal nephrectomy, or the fetal kidney cannot respond to it.
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