Studies on the Agglutination of Erythrocytes Treated with Human Plasmin and Some Other Enzymes ∗

Abstract

Summary

The serological activity of human plasmin was compared with those of trypsin, bromelin, papain, and ficin. Human plasmin increased agglutination of erythrocytes with Rh-Hr antibodies, and to a lesser extent, with anti-Le^a, anti-K, and anti-k (Cellano) antibodies. It did not decrease the agglutination of erythrocytes with anti-M, anti-N, anti-S, and anti-Fy^a antibodies. No increased agglutination could be observed with anti-P and anti-I antibodies. Bovine plasmin, human and bovine thrombin, and α-chymotrypsin did not alter the agglutinability of erythrocytes.