Interferon Action in Heterokaryons

Abstract

Summary

Chick interferon was active in chick red blood cell-human fibroblast heterokaryons, whereas it was inactive in the human fibroblasts without fused chick nuclei. The heterokaryons were much less sensitive to human interferon than were the human fibroblasts without chick nuclei. Both human and chick interferons together were more active in heterokaryons than was either interferon alone. Ribosomal turnover studies in heterokaryons and in the human cells without chick nuclei suggest the possibility that the site of interferon action may not be on the ribosomes.