Abstract
Summary
Isoproterenol, administered subcutaneously in a single dose on the eighth day of gestation to pregnant hamsters produced a variety of gross malformations of the brain, eyes, spinal cord, heart, liver, and skeleton. General and localized body edema was found alone or in conjunction with other anomalies. In addition, the percentages of dead, resorbed, or runt fetuses were increased over those found in control litters. The qualitative and quantitative parameters of the teratogenicity of isoproterenol were compared to those of trypan blue.
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