Abstract
Summary
The antinatriuretic action of growth hormone (bovine) was studied in adrenalectomized rats. A dose-response relationship and a time sequence were determined for the antinatriuretic action of growth hormone. Actinomycin D was administered prior to the hormone to determine the effect of actinomycin D on growth hormone-induced antinatriuresis. The results indicated that the antinatriuretic response of growth hormone was dose related. It was found that a 2-hr delay in onset of action followed the administration of growth hormone. The duration of antinatriuresis was approximately 4 hr and this was observed between 2 and 6 hr after administration. The data show that actinomycin D administered prior to growth hormone completely blocked the antinatriuretic action of this agent. The blockade by actinomycin D suggests that RNA synthesis is involved in this action of growth hormone. The observed delay in onset of action of growth hormone is also consistent with the suggestion that growth hormone induced antinatriuresis is mediated through RNA synthesis.
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