Abstract
Summary
Norethynodrel and mestranol, a progestational and an estrogenic compound, were fed in physiological doses to half of 14 pairs of 83-day-old female rats and half of another 8 pairs that were 35 days old. The control rats were pair-fed exactly the same quantities of diet as those receiving the antiovulatory steroids. Despite the fact that the steroid-treated rats and the control rats consumed equal quantities of diet the control rats were somewhat heavier at the end of 5-weeks feeding. The 83-day-old rats treated with steroids had significantly lesser cross-sectional growth in the tibias than their companion control rats whereas the length of the femurs and the widths of the tibial epiphyseal lines were not significantly reduced. However, in the 35-day-old rats the length of the femurs were significantly shorter in the treated rats than in the control rats.
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