Abstract
Summary
Rhesus monkeys were injected with monkey testicular extract incorporated into Freund adjuvant. All six monkeys developed a histological picture of orchitis. The testicular lesions consisted of congestion and serous edema, with sloughing of germinal cells from the tubules; these cells appeared to fill the epididymis ducts. Lesions were more pronounced between 10 and 13 weeks after immunization. Lymphocytic infiltration was present in moderate intensity in only one animal. Circulating antibodies were detected in a few animals at very low titer; however, following castration the titers increased. The organ specificity of the antibody response could be well documented by means of immunofluorescence. According to the results obtained, auto- as well as isosensitization of rhesus monkeys with monkey testicular material incorporated into complete Freund adjuvant produces histological and serological changes very similar to those seen in human experimental orchitis.
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