A Comparative Study of the Antitumor and Antiviral Activity of 1-β-D-Arabinofuranosyl-5-fluorocytosine (FCA) and 1-β-D-Arabinofuranosylcytosine (CA)

Abstract

Summary

FCA was similar or slightly superior in activity to CA with regard to antitumor effects when tested against the following experimental tumors: ascitic leukemia L-1210, sarcoma-180, Ehrlich solid carcinoma and mammary adenocarcinoma EO 771. FCA was appreciably more active on a mg/kg basis than CA with regard to its effect against the solid forms of leukemia L-1210 in both semi-isologous BDF₁ and homologous albino mice, as well as against Walker carcinosarcoma 256. Both substances were without effect against the Flexner-Jobling carcinoma in rats. FCA and CA exerted similar degrees of antiviral activity against herpes simplex keratitis in the rabbit and vaccinia virus in rhesus monkey kidney cell cultures. Both substances were inactive in vivo and in vitro against the following RNA-containing viruses: Columbia SK, Coxsackie virus B1 (GP), and influenza A (PR8).