Abstract
Summary
In four mongrel female dogs, gastric antral action potentials excited by a constant infusion of water into the lumen of the stomach were markedly inhibited by intravenous infusions of secretin but were not inhibited by similar infusions of cholecystokinin. The data suggest that secretin slows gastric emptying by decreasing gastric contractions whereas cholecystokinin does not. The reduced gastric emptying associated with duodenal acidification may thus be the consequence of release of secretin.
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