Abstract
Summary
The number of nucleoli in myocardial nuclei was determined for human hearts in the weight range of 300-640 g. The variation of nucleolar abundance was significant, but slight, with larger hearts tending to show more nucleoli per nucleus. The maximum number of nucleoli per nucleus was six, regardless of the heart weight. It is concluded that even if the amount of DNA per nucleus increases during the development of myocardial hypertrophy, as suggested by microspectrophotometric studies, the number of potential nucleolar organizers remains fixed at six per nucleus.
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