Abstract
Summary
Animals given nicotinamide either as a pretreatment or as long as 2 hr (but not 4 hr) after streptozotocin were protected from diabetes. Nicotinic acid and NAD pretreatment were ineffective in preventing streptozotocin diabetes. It was postualted that streptozotocin may interfere with NAD formation in the beta cell and that treatment with nicotinamide reverses the streptozotocin effect by reversing its effect on levels of NAD within beta cells.
Get full access to this article
View all access options for this article.