Abstract
Summary
The membrane-associated enzyme adenyl cyclase gives rise to 3′5′ cyclic adenosine monophosphate (cyclic A) within the hepatocyte; and the availability of intra-hepatocytic glucose is determined to a considerable extent by the mobilization of glycogen via cyclic A. Following 70% hepatectomy, a significant turnover of membrane structures occurs concurrently with loss of cellular glycogen. The present study revealed that glucagon and epinephrine activated adenyl cyclase remains at a normal level throughout the regenerative process. These findings suggest that the regenerating hepatocyte is capable of producing adenyl cyclase and inserting it into newly formed membranes.
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