Abstract
Summary
Evidence has been presented that potassium depletion occurs in the skeletal muscle, heart, kidney, and plasma of pregnant rats and in the skeletal muscle and plasma of the nonpregnant rat following chronic administration of 0.6% acetazolamide in the diet for 20 days. A similar pattern of depletion followed two injections of drug spaced 18 hr apart. Sodium recompensation was observed in both pregnant and nonpregnant rat tissue that was partially depleted of potassium. A rise in liver potassium was observed in the pregnant and nonpregnant animal following the injection of 500 mg/kg of acetazolamide on days 10 and 11 of gestation. A similar rise was observed only in the pregnant rat on the 0.6% diet for 20 days.
Get full access to this article
View all access options for this article.