Abstract
Summary
Inhibition of porcine tissue plasminogen activator by ∊-aminocaproic acid (EACA), trans-4-aminomethylcyclohexancarboxylic acid (trans-AMCHA) and p-axmnomethylbenzoic acid (PAMBA) increased uniformly with increasing concentrations of inhibitor. In contrast, with human urokinase an early phase of inhibition at low inhibitor concentrations was followed by a phase of enhancement of fibrinolysis turning into a second phase of inhibition at inhibitor concentrations 300 times higher than required in the first phase. This biphasic inhibition of urokinase distinguishes it chemically from tissue plasminogen activator.
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