Zygote Transfer to Facilitate Altered Expression of Immunoglobulin Light Chain Phenotypes in Homozygous Rabbits ∗

Abstract

Summary

By the techniques of zygote transfer and allotype suppression, b⁵ homozygous rabbits were produced with an altered expression of immunoglobulin light chain allotypes; i.e., at 24 weeks of age, only 27% of the total γG was b5γG compared to 90% in nonsuppressed homozygotes. Of the 73% b-negative molecules, 44% were c7γG and 29% were both b- and c-negative. These results suggest that there may be at least three “loci” which control the synthesis of light chains.