Abstract
Summary
Mice were injected intravenously or intraperitoneally with 3 or 12 μg of S. typhosa endotoxin, respectively. One group received 550 R of X-irradiation 24 hr later. Five days after endotoxin administration all mice were injected intravenously with Ps. aeruginosa. One min after receiving the pseudomonad injection the mice were given 5 mg of Colistin intravenously to kill extracellular bacteria. Livers and spleens were removed from the infected mice 24 hr later, ground, and the number of viable bacteria per organ was determined by culture methods. Heart's blood was cultured for extracellular bacteria. The results indicated that greater numbers of bacteria were killed within the livers and spleens of endotoxin-treated animals than controls. Only the livers of endotoxin-treated X-irradiated animals showed higher bactericidal ability.
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