Abstract
Summary
Macrophage migration inhibition tests of delayed sensitivity showed that trypsinization of sensitive peripheral blood lymphocytes did not affect their mediating ability or production of migration inhibitory factor (MIF). Trypsinization of normal macrophages abolished their response to sensitive lymphocytes or MIF; their ability to respond was recovered when first cultured for 20 hr but not 4 hr. The MIF was absorbed to a greater degree by untreated than by trypsinized macrophages. These findings suggest the presence of macrophage receptors for MIF and the cytophilic nature of the latter.
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