Metabolic Aspects of 4-Aminopyrazolopyrimidine-Induced Fatty Liver in the Rat

Abstract

Summary

The effect of the adenine analogue, 4-aminopyrazolo pyrimidine, (APP) on liver lipid composition, on liver content of ATP, on lipogenesis in vitro in liver slices and on serum lipoproteins in the rat is reported. The effect of ATP and of adenine in APP-treated rats is also presented. The neutral fats in the liver of APP-treated rats increased significantly, while the incorporation in vitro of acetate-¹⁴C into total lipids decreased when compared with the controls. Under the same experimental conditions the concentration of serum lipoproteins fell and the liver content of ATP increased. The administration of ATP to APP-treated rats did not prevent either the development of fatty liver, or the decrease of serum lipoprotein concentration, or the fall in incorporation of acetate-¹⁴C into liver lipids. The administration of adenine to APP-treated rats partially reversed the effects of APP on the lipid content of liver, on the levels of serum lipoproteins and on the incorporation of acetate into lipids.